SAME 200mg 60vcap - Now Foods

SAME 200mg Now supports the Nervous System and helps in the regulation of mood and emotional states.

SAME 200mg Now supports the Nervous System and helps in the regulation of mood and emotional states.

SAM-e (S-adenosyl-L-methionine) is found in every cell and body fluid, where it acts as a methyl donor in over 40 biochemical reactions in the body.

Over the last two decades, numerous studies have shown that NOW SAM-e is effective in the treatment of Depression, Osteoarthritis, and liver disease. Furthermore, SAM-e has a very favorable side-effect profile compared to standard medications.

It has an antidepressant effect by stimulating monoamine metabolism (dopamine, norepinephrine, epinephrine, and serotonin).

Clinical studies conducted in 1973 indicated that SAM-e had antidepressant effects. In the following two decades, the efficacy of SAM-e in the treatment of depressive disorders was confirmed in more than 40 clinical trials. The results of a meta-analysis showed that SAM-e had a significantly higher response rate than placebo and was comparable to tricyclic antidepressants.

The antidepressant effect of SAM-e is of particular interest due to its close metabolic relationship with folate and the association between a high incidence of folate deficiency and depression.

The potential benefit of SAM-e in the treatment of Osteoarthritis was discovered when patients enrolled in SAM-e clinical trials for Depression reported a marked improvement in their symptoms. Nine clinical trials in Europe and 1 in the United States, with a total of over 22,000 participants, confirmed the therapeutic activity of SAM-e against Osteoarthritis. In other words, it has effects similar to non-steroidal anti-inflammatory drugs, but with better tolerability.

60 vegetable capsules