Methyl-Guard Plus 90caps - Thorne

Methyl-Guard Plus 90caps - Thorne

Supports heart, blood vessel, brain, and bone health by improving healthy methylation

Thorne 's Methyl-Guard Plus provides 5-MTHF (active folate) and the active, tissue-ready forms of vitamins B2, B6, and B12 to support healthy methylation for cardiovascular, cognitive, and bone health.

Methylation is essential for keeping homocysteine ​​levels under control, as well as facilitating several biochemical processes involving neurotransmitter synthesis, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Maintaining a desirable blood homocysteine ​​level has linked healthy cholesterol and triglyceride levels as leading biomarkers for maintaining good cardiovascular health. Preventing undesirable homocysteine ​​levels is also associated with maintaining bone, reproductive, cognitive, and female neurological health. Methyl-Guard Plus supports methylation and promotes healthy homocysteine ​​levels with betaine (trimethylglycine), 5-MTHF (the active form of folate), riboflavin 5'-phosphate (the active form of vitamin B2), pyridoxal 5'-phosphate (the active form of vitamin B6), and methylcobalamin.

Various conditions and stressors can adversely impact the body's methylation cycle. For example, nutrient deficiencies and environmental and physical stressors can cause inefficient methylation. Furthermore, a common human genetic mutation that restricts the activity of a key enzyme in the body involved in methylation affects approximately 60% of US adults. This genetic anomaly poses a significant challenge to efficient methylation—and creates an important need for nutritional support to help correct it.

Methylation—the addition of a methyl group (a carbon atom bonded to three hydrogen atoms) to another molecule—is an essential and vital biochemical process involved in multiple biochemical pathways involving neurotransmitter synthesis, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Several specific nutrients are required for methylation processes to occur normally. Maintaining normal blood homocysteine ​​levels is important for good cognitive health. A deficiency in the cofactors that metabolize homocysteine ​​is commonly observed in older adults, resulting in increased homocysteine ​​levels with advancing age. These elevated homocysteine ​​levels associated with aging, as well as low levels of folic acid and vitamins B6 and B12, can result in decreased methylation of numerous substances, including DNA and proteins, which can diminish the integrity of vascular structures and neurons. Therefore, providing nutritional cofactors for homocysteine ​​metabolism supports a healthy brain.

A number of biochemical imbalances that can increase homocysteine ​​levels can be addressed by supplementing with appropriate nutritional cofactors.* These include folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine), which promote the recycling of homocysteine ​​to the amino acid methionine. Additionally, the breakdown of homocysteine ​​into the beneficial amino acids cysteine ​​and taurine can be facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6). Studies have shown that these nutrients help maintain normal blood homocysteine ​​levels.

90 capsules