Indole-3-Carbinol - Now Foods

Indole-3-Carbinol 60vcap - Now

For anti-carcinogenic action

Now's Indole-3-Carbinol helps in the prevention of hormone-dependent neoplasms (breast cancer, prostate cancer, etc.). LinumLife™ Complex (flax seed extract). LinumLife™ is a patented formula rich in flax lignans (intensively researched for their phytoestrogenic effects) that provides flax lignans in concentrations 10 to 30 times higher than other extracts. Patented formula rich in high-concentration flax lignans. Maintenance of a balanced estrogen/testosterone ratio. Has anti-proliferative, apoptotic, and anti-angiogenic properties.

Indole-3-Carbinol (I3C) is a sulfurous phytonutrient found in cruciferous vegetables, such as broccoli. Indole-3-Carbinol has a strong anti-carcinogenic action, particularly regarding breast, uterine, and prostate cancer, by inhibiting the known 16-alpha-hydroxyestrone, a type of estrogen that causes DNA damage and inhibits apoptosis (programmed cell death) of cancer cells, causing these tumor cells to proliferate, which can lead to metastases. Indole-3-Carbinol also maintains a balanced estrogen/testosterone ratio, making it essential for the endocrine system of both women and men. It is also a potent antioxidant and liver detoxifier, an effect that is enhanced by the addition of flax lignans. NOW ensures full stabilization of its Indole-3-Carbinol through cutting-edge processes used in its production. I3C suppresses to varying degrees the proliferation of a large series of tumors including: breast, prostate, colorectal, myeloid leukemia, and it has recently been shown to be effective against adult T-cell leukemia/lymphoma -ATLL- (Aggarwal-2005, Machijima-2009). I3C inhibits the activation of various transcription factors including NF-kappaB, Akt, SP1, estrogen receptor, androgen receptor, and Nrf2 (nuclear factor erythroid 2-related factor 2). This substance enhances TRAIL (Tumor necrosis factor-Related Apoptosis-Inducing Ligand) by inducing cell death receptors and enhances chemotherapy by reducing P-glycoprotein (P-gp) on the neoplastic cell membrane, an agent that removes chemotherapeutic drugs from the intracellular environment. It also has an anti-angiogenic effect. Anti-angiogenic agents are therapeutic agents currently in pre-clinical and clinical research phases that may be useful in the
treatment of malignant diseases (cancers, leukemias, sarcomas, primary bone marrow diseases) that depend on vascular neoformation (angiogenesis) for their growth and metastasis. They are more specific in their mode of action than chemotherapy or radiotherapy agents, which constitute the classic therapies for malignant diseases. Due to their specificity, they are less toxic and better tolerated agents than chemotherapy/radiotherapy. The high fiber content of flax seeds is well known. The polysaccharides – gums and mucilages – of flax seeds can have nutritional value as dietary fiber, which seems to play an important role in reducing diabetes and the risk of cardiovascular disease, in preventing colon and rectal cancers, and in reducing the incidence of obesity.

I3C is a substance that decreases mitochondrial membrane potential.

I3C is a potent chemopreventive agent in hormone-dependent neoplasms such as breast and prostate cancer. These effects are mediated by the suppression of free radicals, inhibition of the formation of carcinogens that damage DNA, stimulation of estrogen 2-hydroxylation (estrogen inactivation), inhibition of angiogenesis, and induction of apoptosis. Additionally, there is strong hepatoprotective activity against various types of carcinogens, due to the induction of the p-450 enzyme (Safe-2008, Aggarwal-2005, Sarkar-2004, Manson-2005, Kim-2005, Naugler-2008, Mori-1999).
60 Capsules